Many approaches to the psyche, models of therapy, and neuroscience tend to view emotional and cognitive brain functions as separate entities. Such a focus on one of these two aspects of mental function, at times comes at the expense of ignoring the other. In this paper emotions and cognitions, along with perceptions and other elements of the internal and external contexts, are viewed as relevant vectors in a matrix of information. Through the processes of pattern completion and noise reduction, information in each of these vectors may evoke memories in the same or other vectors that are used in the formation of a subjective understanding of each experience. The important roles of the external (physical, temporal, relevant events, etc.) and internal (emotional, affective, hormonal, medications, etc.) contexts in the formation of such subjective experiences will be discussed. The use of this view in broader and more comprehensive psychotherapeutic approaches and combined pharmacological and psychological treatment is explored.