Meaning making is a central component of the therapeutic process, and there is a reciprocal relationship between experience and the interpretation of the experience. Interpretation and verbally achieved insights are relational experiences, and interaction is itself interpretive and conveys meaning. Most clients remember special “moments of meaning”; authentic person-to-person connection with their therapists, moments that altered their relationship with him or her, and thereby their sense of themselves. These moments of intersubjective meeting constitute a pivotal part of the change process; deep, authentic affective experience and its regulation through co-created emotional interchanges between client and therapist. Focusing on two facts about human beings; we are embodied and in relationship, this paper offers clinical vignettes which illustrate such “moments of meaning” and considers both theoretical and therapeutic perspectives.