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The paper offers a reflection on some highly innovative aspects of Mauro Mancia's work concerning the extension and research of psychoanalysis in the encounter with other disciplines, namely neuroscience, physics, and biology, and the extraordinary contributions that can result from opening up to new epistemological paradigms. In particular, Mancia's studies on the primary dimension, on the role of sleep as a container in which the basis for the formation of an early form of psychic activity is laid, on the dream as a pre-symbolic experience, and on the forms of communication between mother and child in which the maternal voice constitutes the means by which words create the sounds that convey affects are explored in depth. A dimension that refers to the transference field of care, to the dreaming co-construction of the analytic scenario, where the affective states projected in the analyst's mind, which solicit his or her «negative capacity», necessarily concern an interbody dimension between two psyche-soma arrangements that achieve states of syntonisation, interchange, and continuous contamination in a transformative key.
KEY WORDS: Affect, dream, intercorporeality, neuroscience, psychoanalysis, sleep.