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The production of the fifth edition of Diagnostic and Statistical Manual of Mental Disorders (DSM-5™) was, according to the volume's introduction, a twelve-year process with many complex interactions among the editors and a variety of mental health practitioners and researchers, both proponents and critics of the process. I will describe the organization of DSM-5, address some critical evaluations of the new edition and how it was created, and compare it to the NIMH Research Domain Criteria (RDoC). I will address the volume's value and limitations (the latter include its lack of a narrative section and its jettisoning use of the Defensive Functioning Scale and the Global Assessment Functioning Scale, which should have been replaced with the Global Assessment of Relational Functioning Scale). I propose that the biopsychosocial model can be integrated into psychiatric nosology via the incorporation of principles from narrative medicine. As an example of in-depth analysis of all the disorders catalogued in DSM-5, I briefly discuss the new and controversial diagnosis of Disruptive Mood Dysregulation Disorder (DMDD) to illustrate the value and the limits of DSM-5.