Applying an eclectic psychoanalytic framework, this paper provides a thematic link between the core experiences of Williams' early life and his creative work. Both preoedipal and Oedipal themes are elucidated. The central issue that dominated Williams' mental life was his struggle between a sense of suffocation and confinement, on the one hand, and having artistic and sexual freedom, on the other. The experience of suffocation extended to his dread of becoming mad. This dread derived from his intense twinning or twinship merger with his schizophrenic sister who was confined in an asylum. The study focuses attention on a number of Williams' one-act and full-length plays, written during each of the decades of his public career, as representative of his overall dramatic opus. These works are indicative of his special relationship with his sister as well as of his obsession about self-indulgence and fear of confinement. The later plays suggest that he was subject to identity confusion.