This paper presents a framework for school-based health promotion and prevention programming that can serve to guide planning and action. Rather than separating specific prevention programs (such as violence prevention, substance abuse prevention, etc.) from more broad-based youth development efforts, this approach provides an integrated framework that: (a) identifies benchmarks of healthy development and strategies to support this development across contexts; (b) specifies additional factors that contribute to identified problems that are not directly linked to healthy development; and (c) provides for matching services to individual needs. Suggestions for application of this framework are discussed, with a particular focus on its application to the development of school-based Wellness Centers.