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George MacLean graduated from medical school from the University of Saskatchewan, Saskatoon, in 1966. After an internship in Calgary, he served as a medical officer with the Canadian Armed Forces stationed in Germany. Once he returned to Canada, he studied psychiatry and completed his residency in child and adolescent psychiatry in 1974 at the McGill University. Upon graduation, Dr. MacLean was on staff at the Montreal Children's Hospital. He also became an assistant professor in the Department of Psychiatry at McGill and trained as a psychoanalyst at the Canadian Institute of Psychoanalysis, Quebec English Branch, graduating in 1981.
In 1983, Dr. MacLean moved to Ottawa. He was an associate professor of psychiatry at the University of Ottawa and the first director of training in the Division of Child and Adolescent Psychiatry at the University of Ottawa. George had published more than 20 papers, mostly on the therapy of children and adolescents and child psychiatry. In 1991 he published a book with Ulrich Rappen, Hermine Hug-Hellmuth, the first psychoanalyst practising with children. He was honorary secretary at the Ottawa Institute of Psychoanalysis and taught both at the Quebec English Branch of the Canadian Institute of Psychoanalysis and at the Ottawa Institute of Psychoanalysis. He was active in the Ottawa Psychoanalytic Society, serving on the board and in various committees. After moving to Toronto he continued to serve on a number of committees in the Toronto Psychoanalytic Society.