In Hobson's model, the dream is a psychological event initiated and shaped by the functioning of the brain during sleep. Hobson's study of isomorphism between brain function and dream imagery has the potential to add another dimension as psychoanalysts think about the determinants of the dream from the point of view of the brain and neurobiology. I intend to explore briefly what Hobson's ideas may offer psychoanalysts about the form of the manifest dream and about the functioning of REM sleep in developing the brain's capacity to predict experience in the external world. I hope to interest Hobson and colleagues in other disciplines in the role of psychological defense in the selection of imagery in the manifest dream and in the functioning of unconscious motivation in the construction of internal models of reality.