This essay endeavors to situate notions of transcendence historically, philosophically, religiously, and experientially. Thereby arises a case that is fundamental to the clinical process of psychoanalysis is a transcendent effort to alter lived reality, the very scope of being. More than for symptom reduction, improved adaptation, or cure, psychoanalysis works to loosen those transferential habits of egotistical mind that defensively constrict one’s ways of being in the world. Elements of uncanny or mystical experience and of psychedelic therapeusis are pertinent to this transcendent viewpoint, this “overmind.” Transcendence of egotistic self becomes an escape from dualistic self-versus-other, an escape toward freedom, humanely being with, for, and fundamentally of one another.