This article addresses forms of political resistance, clinical and extra-clinical, that aim at types of knowledge and ways of being in the world that are life-enhancing, broadly speaking, and that may, at the same time, resist some contexts of intimacy. More particularly, positive and negative forms of political resistance are defences against and subversions of social, cultural, political, and economic ideas, laws, policies, programs, and institutions that (1) undermine subjective and intersubjective experience of being valued or worthwhile and (2) restrict certain individual's and group's public-political space. As defences, these negative and positive forms of political resistance are attempts to instantiate a type of knowledge and concomitant shared speech and action that embody mutual recognition of individuals as persons; valued, unique, inviolable, and responsive/agentic.