The profound psychic differences between the two human sexes are also reflected in their diverse psychopathology, even though the basic clinical forms remain common for both. In this study the problem of the psychoanalytic difference between the two sexes is discussed within the framework of psychotic situations; in intrapsychic relationships with the mother and the father, and between the patient and the therapist and with his sex. The problem of masculine and feminine psychosexuality is furthermore seen in a different light, in accordance with its pre- or postoedipal configuration.