This paper discusses Freudx's theory in the context of the most significant redefinitions in contemporary biology. Freud's ideas in general, as well as his conception of mental illness, were deeply grounded in the paradigm of evolutionist biology, which prevailed during his lifetime. Over the last four decades, another paradigm emerged in this field and became dominant, i.e., the informational paradigm. For this reason, some of the implications of this new paradigm for resigifying Freud's concepts like repetition, death drive and anxiety will be outlined.