The author presents a historical overview of the evolution of the German journal Psyche, starting from its foundation by Alexander Mitscherlich, Felix Schottlaender, and Hans Kunz in 1946. After the gradual reorientation of Psyche in the direction of being a purely psychoanalytic journal, Mitscherlich became its sole editor in 1969. In the 1980s, Psyche played a central role in the discussion and working-through of the German analysts' involvement in the National Socialist Regime. In 1997, Werner Bohleber followed Margarete Mitscherlich as editor-in-chief. Psyche, the only monthly psychoanalytic journal in the world, keeps not only documenting, but also shaping the main developments taking place in our field, on both a national and an international level. As far as the last 20 years are concerned, the journal has also played a central role in the debate conducted in and outside Germany in terms of empirical research in psychoanalysis and the dialogue with the neurosciences.