Posing the question of the possibility of transference at the moment of a decompensation, the author proposes rethinking the psychiatric concept of “unmotivated laughter” in light of psychoanalytic experience, taking a case study as a point of departure. In the present research, the intention is to understand the rule of laughter outside the conception of the joke (Witz), by tracing the trajectory of the conceptualization of laughter from Freudian to Lacanian psychoanalysis. This review is needed in order to understand an experience of interpretation of laughter at the time of a decompensation in the schizophrenia of an adolescent, in which (un)motivated laughter formed a symptom. “Jouissance-laughter” necessitates changing the psychiatric understanding of laughter in schizophrenia, where its motivation is not what is comical in the here-and-now. In this laughter, the humorous or comic response of the clinician becomes an interpretation.