The present paper is an expansion of the author’s discussion of Harold Blum’s seminal presentation “Hate and its vicissitudes” in Prague in 2017. It aims at an elaboration of various aspects of hate and hatred as a complex dynamic intrapsychic and relational affective-cognitive state, alloyed, in different ways, with aggression and love. In this context, various theoretical perspectives concerning the multifaceted relation between hate, love, and sexuality, and hate and destructive aggression, and transformations between them, including the first study of neurobiological correlates of hate, will be raised and explored. Implication on destruction as well as psychic structuring, adaptation and creativity are also considered. The clinical vignettes illustrates the relevance of multiple theoretical conceptualizations in contemporary psychoanalytic practice.