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Psychoanalysis and psychoanalytic psychotherapy have evolved deeply over the past half century. This paper shows some the changes I have witnessed in them, and the challenges we face in this change of era, at the edge of the first quarter of the twenty-first century. Some the challenges are examined: knowing how to transmit in our daily practice the essential relationality of the human being; the relational essence of the process of change through psychotherapy; and a review of our contribution to our institutions being genuinely relational, that is, that we take more care of the space that the Other can inhabit than of preserving our own. We need hope: the hope to change and (again) be people, in connection with others, regaining confidence and being able to be ourself (to be ourselves with others). That is the meaning of our activity, what it is to be a psychoanalyst/psychotherapist today.