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We reflect on the concept of the setting in psychoanalysis, and how it has been radically reconsidered given the impact of the SARS-CoV-19 pandemic on human interactions and moving from face-to-face to online sessions. The rapidity of going from seeking interaction to a fear of possible contagion led some professionals to adopt a sudden change of setting. Although the concept of setting seems to come from the classical Freudian method, Freud never spoke about it explicitly, although it was subsequently developed from his writings. Only in the 1960s and 70s was the setting perceived as the very object of psychoanalytic exploration. Since the psyche in psychoanalysis is conceived as a spatially extended entity, this paper discusses the concepts of space and time (external setting) and the mental state of both the patient and analyst (internal setting). We investigate how these aspects have changed as a result of the use of technology. What changes have taken place at the perceptual level in the patient and analyst? What differences are there with respect to the presence/absence of the other’s body? We use our own reflections of our personal experiences of undergoing face-to-face and online sessions to reveal the differences between them.