This paper asks what is evidence-based psychology and looks at the ways in which psychoanalysts have sought to engage with the challenges posed by this method of deciding best science. The paper examines the evidence for the evidence-based method and looks at how psychoanalysts have attempted to shift the scientific debate from evidence-based models to practice-based, outcome driven models and, ultimately, to a patient-therapy approach that seeks to marry best practice with a spirit of open-minded assessment of alternatives.