The aim of this paper is to explore how Shakespeare drew on contemporary life to assist society to manage profound loss, uncertainty and anxiety. This was achieved through providing a forum, both in the “here and now”, via the plays and other works, and through creating a body of work for future generations to mine. This evolved over time to penetrate and fertilize the global community. In these ways Shakespeare helps us all to metabolize anxiety and despair and continue to move forward in the struggle of life. The paper includes a detailed discussion of the interpretations and applications of the works and their relevance to professionals who work within the space in which suffering and despair inhabit.