Existential analyses of Murakami's fiction have dealt mostly with identity issues during adolescence and adulthood. This article presents a different existential conceptualization by examining how Yalom's four ultimate life concerns—isolation, meaninglessness, freedom, and death — are embodied in the life of some of Haruki Murakami's fictional protagonists. In this work, I will also bring standard diagnostic nomenclature and psychoanalytic conceptualizations into dialog with the existential tradition, by demonstrating how certain mental conditions, which are considered by clinicians as forms of psychopathology, can also be interpreted as modes of existence in an alienated reality, and as non-conformity.