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Freud has always considered psycho-analysis as biological science, and has always given special attention to the organic life. In Beyond the Pleasure Principle he has given particular attention to the biology of protozoa. According to psycho-analysis the same fundamental laws occur in the organism and in the psyche. Analytic theories have partially been developed under the influence of biology. Psycho-analysis, which gives a deep insight into the structure of the psyche, which is the most important biological function, is certainly able to help the biologist and draw his attention to problems which he would have neglected otherwise. Mendel has taught us that the appearance of the organism does not show its real potentialities. The genotype is different from the phenotype. Biological qualities can remain, therefore, suppressed. We deal with an analogy to the mechanism of repression. The experiments of Driesch and Spemann have shewn that many of the potentialities of the single cell remain potentialities and do not become realities. The organism never exhausts its possibilities completely. The biological total situation determines which potentialities of the cell become realities. The inner plan of development necessarily represses many prospective tendencies. The experiments of M. Hartmann shew that protozoa can live for ever. These experiments speak against an inner tendency to death. It is even possible to keep 'Amoeba proteus' alive without cell division, if one hinders them by amputation from becoming too large. The tendencies of self-preservation, which correspond to the ego instincts of psycho-analysis, fail only when they want too much. These facts point to a theory that death is not the result of an inner urge, but the result of unorganic events in the organism which can be compared with earthquakes, lightning and other catastrophes in the outward world which have no inner meaning. Sexuality and fecundation are independent from propagation.