This paper arises out of a remark made by Freud, that biological medicine is treading on the heels of psycho-analysis. The co-existence and interdependence of psychic and organic processes is emphasized and some experimental evidence of bisexuality is instanced. The organic processes involved in anxiety states are considered in relation to constitutional conditions, and the possible limitations to the therapeutic achievements of psycho-analysis are regarded optimistically. Examples and illustrations of the organic repercussions of psychic events are given, including shaking palsy, constipation, obesity and dieting, asthma, and excessive thirst. Unconscious control, either stimulating or inhibitory, is shown to be exercised in all normal and neurotic functioning. The euphoria of those in the last stages of pulmonary tubercle is accounted for by the gratification of oral and respiratory eroticism. Finally it is urged that analytical and medical problems should be approached simultaneously from both aspects.