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Abstract
The central subjects of this paper are two large-scale clinical trials. They are the German multicentre trial, die Langzeittherapie bei chronischen Depressionen (LAC) and the London based, Tavistock Adult Depression Study (TADS). Their outcomes will be published in the psychiatric literature in the first half of 2015. Their principal purpose has been to evaluate the effectiveness – or otherwise - of psychoanalysis and psychoanalytic psychotherapy as modes of treatment for patients suffering from chronic or longer term forms of depression; in the case of one of the Studies it is those forms of depression which have sometimes been referred to as treatment-resistant. Each of the Studies has aimed to gather the kind of outcome evidence which increasingly is required by their respective country’s healthcare funding institutions while as well carrying out in-depth psychoanalytic clinical research. The paper considers what is involved in meeting these objectives