In the article a phenomenon of thanatization is presented. In clinical practice, this phenomenon manifests itself in its extreme form as the machine syndrome. Thanatization is a manifestation of death drive, which according to fundamental definition aims at coming down of live beings to inanimate state, that is bringing the tension in organism to level zero. Some extracts of analytical work with two schizophrenic patients are presented. Described patients are Mr A and Mr C who developed the machine syndrome. In the material, lifeless mental representations of self and object are dominant. These patients reduce self and object to a role of automatic machine that is to the role of inanimate objects. The contribution of psychoanalytic authors to understanding a concept “thanatization” is discussed here. Referring to psychoanalytic concept of death drive, a concept of thanatization is formulated, namely cathecting of self and/or object with death drive. By bringing mental representations to inanimate form, death drive causes almost complete reduction of tensions in object relations and one's own self, also causing death of any desire and lack of anxiety.