In the Lacanian frame hysteria is a subset of neurosis animated by the inability of the Symbolic to write Woman or, as Patricia Gherovici (2010) suggests, by the impossibility of writing two sexes with one (phallic) signifier. The discourse of the hysteric generates questions central to transgender (trans) studies and feminist psychoanalytic theorizingboth of which are concerned with something in excess of the phallic premise. In this paper, I suggest that those identifying as trans, like hysterics, are comparatively animated by, and attuned to, the impasse of sexual difference theorized by Lacan. A wish for a medically assisted transition may correspond with the hysteric's desire to reckon with the phallus as it underwrites two sexes with one (phallic) signifier. In this article I use Bracha L. Ettinger's theory of the matrixial borderspace alongside Lacanian theory, to suggest that there is a genealogical link between hysteria and trans subjectivity. Ettinger's theory of the matrixial borderspace prompts us to consider trans subjectivity as involving an attunement to an Other axis of difference before, alongside and beyond the phallic premise theorized by Lacanan axis of difference irreducible to identity, sex and gender normally conceived in Oedipal cisgender (non-trans) terms.