There is consensus within psychoanalysis and psychodynamic psychotherapy that initial interviews might play a fundamental role for both treatment process and outcome. The Three Level Model (3-LM) is a clinical tool that promotes group discussion to assess if there have been transformations in the patient, throughout a psychoanalytically oriented treatment. Although the 3-LM has been used for a decade within the International Psychoanalysis Association, it is still necessary to study its validity and reliability. OBJECTIVES & METHODS: Analyzing a single case of focused psychodynamic psychotherapy, this study evaluated change hypotheses inferred from the first 4 interviews by a 3-LM group and compared them to outcome measures after nine months of treatment. Outcome Questionnaire OQ.45.2, Symptoms Checklist SCL-90 and OPD-2 criteria were employed to estimate the patient’s symptomatic and structural change, respectively. RESULTS & DISCUSSION: There were major convergences among change hypothesis formulated within 3-LM and the outcome measures at nine months of treatment. However, there were some divergent points in the analyzed data. Results show a first step towards reliability and validity of 3-LM Model, and the OPD-2’s contribution to psychodynamic practice-oriented research. Implications focused on 3-LM and OPD-2 criteria as well as future research are discussed.