The psychodynamic perspective, originating from Sigmund Freud's seminal work on the structure and dynamics of the human mind, has laid a robust foundation for understanding mental processes. Freud's conceptualization of the mind's tripartite structure — the id, ego, and superego — and the accompanying theories of ego, object relations, and self-psychology have profoundly influenced the field of psychology. While Freud recognized the neural underpinnings of these mental constructs, the neuroscience of his time was limited in its capacity to elucidate the intricate workings of the mind as he had postulated. With evolutionary discoveries, it is now possible to look at Freudian propositions alongside these and propose a holistic understanding of the integration. This paper aims to draw a parallel between the evolution of the human brain in adapting to novel stimuli and the unfolding of the human psyche as described by Freud. It is intriguing to investigate how the synergy between these two disciplines can enhance our understanding of the brain's organisational principles and the functional connectivity among different brain regions in relation to the development of the ego and superego.