A transcribed interview with a psychiatrist, Dr. E, is presented, focusing on the understanding and treatment of psychotic states. Dr. E, a dedicated clinician who has devoted much of his long career to the study of the psychoses, prefers anonymity in order to be able to speak freely. The topics covered include annihilation states, hallucinations and delusions, the origins of psychotic states in the failure of sustaining human relationships, and considerations regarding psychotherapeutic intervention in the psychoses.