How we understand and experience ourselves, others, and the world is impacted by more than typically considered psychodynamic factors. Our neuropsychology additionally shapes how we attribute meanings to interpersonal experiences. This article integrates often overlooked neuropsychological factors with psychoanalytic perspectives by looking specifically at the role of sensorimotor and language systems in shaping relational dynamics and subjective meanings. Using a self psychological framework, this discussion expands our understanding of the selfobject experience by fine-tuning a consideration of what can be meaningfully used within interpersonal dynamics, similar to Winnicott’s concept of the capacity for object usage. Additionally, it adds relational and intersubjective perspectives to consider the interplay of mind-body-brain factors within the relational environment and the progressive, reciprocal nature of the co-created meanings, while also emphasizing the importance of looking outside psychoanalysis to build interdisciplinary bridges within psychoanalytic clinical thinking.