After a historical survey in which the history of the term “psychosomatic” and its invention during the 19th century are retold, as is also the history of modern psychosomatics, the author offers a more personal view, the result of her experience as a classical psychoanalyst and as a practitioner for 27 years at the Paris Institute of Psychosomatics. She develops her current understanding of the theories of the Paris School of Psychosomatics, and selects and elaborates a certain number of concepts essential for clinical work with patients suffering from somatic illnesses. Detailed case studies of two very different patients who are both ill with cancer offer an attempt to show the relevance and application of this specific approach, but which still remains based on psychoanalysis and the most rigorous Freudian metapsychology.