Through a case study, the importance of supporting the positive transference is stressed—from both a psychological and neurobiological perspective. The article argues that the neurobiology of expectation underlies transference. This neurobiology has been investigated particularly over the past several decades in work concerning the placebo effect. By understanding the neurobiology of expectation, one gains a better understanding of the neurobiology of the transference. This enables clinical predictions—and decisions—that are informed not just by the teachings of psychology but also by the science of biology.