Psychoanalysis has been faulted in some quarters for neglecting the “spiritual” concerns of its patients and the place of “spirituality” in its understanding of the mind. In this essay I shall address these challenges, providing a critical review of some of the recent literature on psychoanalysis and religion. I shall then propose an appropriate clinical approach to such issues, addressing recent challenges to the classical concept of “analytic neutrality,” and comment on some current sociocultural matters that seem to me to be relevant. Brief clinical vignettes will be provided in support of my argument.