As a general rule, adolescents suffering from severe organic diseases experience more difficulty than adults and children in recognizing the illness and undergoing treatment, because there is a conflict between accepting the sick body and the sexual body. Dependence on medical treatment, moreover, clashes with the normal drive to autonomy. Long experience as a consultant psychiatrist in the haematology department of a hospital enables the author to propose a hypothesis as to the emotional significance of Hodgkin's disease and chemotherapy, concentrating particular attention on the refusal reaction to the chemotherapy itself. The psychoanalytical psychotherapy of a female adolescent suffering from Hodgkin's disease is presented and discussed to illustrate the theoretical and technical implications.