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The paper investigates the effect of brief early intervention on parental stress in the midst of a socio-economic crisis, such as the one that struck Greece in the past decade. During this period, a psychoanalytically oriented prevention programme with parents and their infants/young children, named ‘Early Intervention Programme’, was designed and implemented in the Department of Child Psychiatry at ‘Aghia Sophia’ Children’s Hospital in Athens, Greece. The families that attended the programme were asked to participate in a research study regarding its effectiveness; data were collected from 102 mothers and 73 fathers. This paper presents the statistical findings regarding parental stress, mainly because it is a factor that has systematically been shown to negatively influence several aspects of a child’s development, but also because our hypothesis was that parental stress would be influenced by the negative external conditions. The results showed that both mothers’ and fathers’ stress levels were high before their participation to the programme (with fathers’ Total Stress scores falling within the clinical range), while they decreased to a statistically significant level after the completion of the programme. These findings are discussed in conjunction with some illustrative clinical material. Based on these, it is argued that the implementation of a psychoanalytically oriented brief early intervention programme with parents and infants/young children can alleviate parental stress, and thus support the parental capacity to efficiently deal with the high demands of early development, even in periods of economic crisis where the tensions for young parents are significant and the available mental health resources are scarce.