This article presents an analysis of the detrimental effects of intergenerational dynamics of trauma on infant psychoneurobiology. It examines how relationally impoverished environments disallow typical development of the right brain. There exists an advanced relationship based model of psychotherapy for the mother and her infant. This clinical approach uses interactive affect attunement to foster healthy psychobiological transactions and normal neurobiological maturation. The therapist's own affect regulation and attuned self-awareness give form to a new relationship between the mother and her infant. Mother infant psychotherapy repairs broken hearts and transforms intergenerational dynamics of trauma.