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The Circle of Security (COS) intervention aims to teach caregivers to become more responsive to their children’s needs. The present study is a meta-analysis that examined the efficacy of the COS intervention in relation to child attachment patterns, quality of caregiving, caregiver self-efficacy, and caregiver depression. Studies were eligible if they carried out a version of the COS intervention and provided quantitative data amenable to meta-analysis. A total of 10 studies were determined eligible for this meta-analysis. A random effects model was used and Hedge’s g was calculated for the overall effect sizes. Results indicated a medium effect size for the efficacy of the intervention for child attachment security (g = 0.65, p = .003, k = 4), quality of caregiving (g = 0.60, p = .012, k = 4) and reduction of caregiver depression (g = 0.53, p < .001, k = 3). There was a significant large effect for improved caregiver self-efficacy (g = 0.98, p < .001, k = 2). Results suggest that while the efficacy of the COS intervention demonstrates promising results, more research is needed.