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This article gives a definition of this patient population and the prevalence together with the high costs to the NHS of these common but very debilitating conditions termed medically unexplained symptoms (MUS). Previously known as psychosomatic conditions, MUS has been newly named in the DSM5 as somatic symptom disorder. The patient mind-set and experience is presented as well as the rationale for an innovative approach called The BodyMind Approach™ (TBMA). Finally best practice tips, drawn from our experience of delivering groups for people with MUS, is offered to colleagues who are working with people with MUS.