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The author explores challenging, complex questions raised by Domenico Agresta and Alessandro Giannandrea, psychologists based in Pescara, Italy. Molino addresses issues critical to the practice of psychoanalysis including: how we understand the analytic setting, how we work with preverbal patients, how we know if change has occurred in the patient, and how changes in culture and society are affecting psychoanalysis. His observations include enlightening clinical examples from his own practice.