David Milrod's target paper and seven commentaries were shared with me for a more global commentary from a neuroscience perspective. We all realize that this important topic—the nature of the self—is also the most untractable in both neuroscience and psychoanalysis, but I do this in the open spirit that is so well communicated in the target article. Milrod's hope was that his effort “might catch the interest of neuroscientists” so that together we “could begin to build a fragile