In “Neuropathologies of the Self: A General Theory,” Todd Feinberg discusses the neurological basis of various defense mechanisms and postulates a hierarchy of them. He thereby presupposes the concept of localization in the brain. In my commentary, I discuss the concept of localization in both its empirical and conceptual aspects and contrast it with an alternative approach, a more holistic one to the function of the brain. This pertains to the question of how information is coded in the brain which in turn is central for the kind of neural structure and organization the brain itself employs in its own processing of stimuli and their related information.