Todd Feinberg's Target Article, “Neuropathologies of the Self: A General Theory,” offers a way to integrate top-down and bottom-up theories of pathological behavior. Feinberg uses the methodology of both behavioral neurology and psychoanalysis to create a unique synthesis that is greater than the sum of its parts. This approach allows for a discussion of meaning in the clinical investigation of neuropsychiatrie disorders. Feinberg's work has broad implications for clinical educators who are charged with the responsibility of helping their students to integrate all the complex aspects of psychopathology. Possible applications for the use of this model in contemporary psychiatric training are considered.