Panksepp, as the true founder of the field of affective neuroscience, has predicted that the understanding of the emotional systems of animals will lead to understanding on the nature of human feelings. The Target Article that we comment on most convincingly shows a careful analysis of impaired SEEKING function for the clinical entity of major depression. It becomes increasingly clear that certain affective imbalances of this and other disorders (e.g., addiction) converge on a common subcortical emotional system, the very SEEKING system that Wright & Panksepp discuss. We conclude our comment with the first report of actual medial forebrain bundle (SEEKING system) stimulation results in humans, treated for therapy refractory depression and performed by our group.