It gives me great pleasure to respond to Otto Kernberg’s commentary on my “New Project for a Scientific Psychology” (2020). It is gratifying to receive praise from a psychoanalyst of his stature. Many other leading colleagues are still ideologically opposed to neuropsychoanalysis, which is nothing short of tragic for the future of psychoanalysis. Hopefully this commentary will persuade some of them to rethink their positions. In my response, however, I will focus on the few areas of disagreement between Kernberg and me.