The 21st Congress of the International Neuropsychoanalysis Society took place in San Juan, Puerto Rico, after two years of waiting because of the lockdown due to the Coronavirus pandemic. The Congress used a hybrid format for the first time to include people who were not able to travel to San Juan. The theme of the Congress was “Neuropsychoanalysis: Implications for Clinical Technique.” The audience had the opportunity of listening to presentations that covered various topics such as memory and learning, transference, the brain explained for the psychodynamically-minded and vice-versa, psychopathology and psychotherapy, modifications to the technique based on neuroscientific findings, clinical praxis and supervision, developmental perspectives, using affective neuroscience in the clinical setting, perspectives on brain injury, emerging psychoanalytic perspectives, research enriching neuropsychoanalytic models, and case presentations.