The work of Gilles Deleuze and Félix Guattari is experiencing a considerable revival in the early twenty-first century, among queer, disability, economic justice, and environmental activists, but also among psychoanalysts across a global geographical range. This essay revisits the key coauthored text of Anti-Oedipus (1972) - with its innovative mix of ideas taken from the work of Wilhelm Reich, Melanie Klein, Jacques Lacan, and Frantz Fanon - as well as an array of Guattari's subsequent writings in order to make an argument for Guattari as not just a critic of stultifying existing forms of psychoanalysis but also as a highly creative revitalizer of the psychoanalytic project. This project was, under the impact not least of the sexual revolution, feminism, and gay rights as well as New Left, anticolonial, and antiwar activism, undergoing substantial transformation as the locus of intensive productivity was shifting from the US to Western Europe and Latin America.