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Schizophrenia was the twentieth century's paradigmatic form of madness. Not only did it emerge as a diagnosis in the early years of the century and then cut a swathe through asylums, hospitals, and laboratories - not to mention literature and art - but this disconcerting form of psychosis also became emblematic of mental health professionals’ angst over fragile boundaries. Schizophrenia was at the centre of many twentieth-century debates about the distinctions between normal and abnormal, neurosis and psychosis, mind and brain, and - as the book under review reminds us - the era's two duelling approaches to making sense of madness: psychiatry and psychoanalysis. It is the fraught nature of this latter boundary, and schizophrenia's influential role in shaping it, that is the subject of Orna Ophir's Psychosis, Psychoanalysis and Psychiatry in Postwar USA: On the Borderland of Madness. Ophir's account tracks how American psychoanalysts understood and articulated their field's expertise in treating schizophrenic patients throughout the twentieth century, training attention on how their theories and ideals for clinical practice changed in response to sweeping developments in the field of biological psychiatry from the 1950s onward. The ‘neosomatic revolution’ in psychiatry, in which schizophrenia and other psychoses were argued to