Replacement therapy should be given only after a careful psychological study of the patient's personality before and after castration. Indiscriminate administration of sex hormones may do more harm than good.

Four detailed case histories use as a measure of the effect of the therapy, the frequency of intercourse and the content of dreams. For a thirty-three-year-old woman, psychotherapy alone was used and with good results in alleviating the symptoms of insomnia and diminution of sexual drive which appeared after both ovaries had been removed because of carcinoma. A forty-two-year-old man had both testes removed. Observed for two years, he received during this time testosterone propionate and, as controls, estrogenic substances and placebos. This experiment showed an undoubted effect of the testosterone propionate on the patient's sexual activity and changes in the character of his dreams.