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The main theories of the etiology of dementia paralytica are discussed. The case history and mental status of a twenty-five-year-old white male suffering from a psychosis with luetic meningoencephalitis is presented in detail. As the usual means of treatment produced no change, thirteen metrazol injections were administered. This therapy had a very beneficial effect, as judged by psychiatric evaluation and a battery of psychological tests. The authors believe that their observations support Hollos's and Ferenczi's interpretation of the paralytic psychosis.