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Karnosh discusses the relation between allergic reaction and nervous disease and points out that the allergic reaction involves every level of the nervous system, from the highest to the lowest elements. He discusses briefly some clinical manifestations of allergy which still are ill-understood, such as the selective action upon the circumflex nerve following horse serum injection for tetanus prophylaxis. He elaborates on a case of dementia præcox in which, during insulin therapy, a remarkable congruity was observed between the mental condition and a concomitant allergic dermatitis. Several paragraphs deal with the personality changes which result from the allergic condition and their care and treatment during the formative years. There is an excellent psychosomatic evaluation of the skin as a powerful organ of emotional expression. Karnosh concludes by saying that emotions and allergy are 'interlocked' and that it is beyond dispute that one influences the other. However, rather than search for which is cause and which is effect, he prefers the assumption of the occurrence of two afflictions concomitant in the same person.