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This is another long review of the immense literature investigating the organic and physiological aspects of schizophrenia. No unfamiliar conclusions emerge from Shattock's own work nor from the two hundred ninety-three papers cited. However,
for the psychiatrist wishing to keep in touch with such researches, there are a few new facts and viewpoints.
Carbon dioxide inhalations inexplicably re-established menstrual cycles in ten of eighteen female schizophrenics who had suffered prolonged amenorrhea. Since the inadequate metabolic response of catatonic patients to cold or the stress of muscular work suggests a pituitary inadequacy with secondary thyroid and adrenal dysfunction, the adrenocorticotrophic hormone (ACTH) is a current object of suspicion. Also psychotic patients are making unusual lymphocytic responses to hormone injections and various stresses. Most of the studies agree that the schizophrenic fails to respond physically and mentally to increased demands made on him by altered external circumstances, including those of experimentation.